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PF-4618433
🥰Excellent
Catalog No. T22397Cas No. 1166393-85-6
Alias PF4618433
PF-4618433 is a selective PYK2 inhibitor with osteogenic activity.
PF-4618433
🥰Excellent
Catalog No. T22397Alias PF4618433Cas No. 1166393-85-6
PF-4618433 is a selective PYK2 inhibitor with osteogenic activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $330 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PF-4618433 is a selective PYK2 inhibitor with osteogenic activity. |
| Targets&IC50 | PYK2:637 nM |
| In vitro | PF-4618433 is a PYK2 inhibitor with an IC50 of 637 nM. PF-4618433 promotes bone formation in human mesenchymal stem cell (hMSC) cultures. [1] PF-4618433 (0-0.3 μM, 24h) significantly increased the proliferative activity of osteoblasts and promoted the differentiation from immature mineralized osteoblasts to mature osteoblasts. [2] |
| Alias | PF4618433 |
| Molecular Weight | 445.52 |
| Formula | C24H27N7O2 |
| Cas No. | 1166393-85-6 |
| Smiles | O=C(NC1=CC(=NN1)COC=2C=NC=CC2)NC3=CC(=NN3C4=CC=C(C=C4)C)C(C)(C)C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (179.57 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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