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PFI-2

🥰Excellent
Catalog No. T1987Cas No. 1627676-59-8
Alias PFI2, PFI 2, (R)-PFI-2

PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.

PFI-2

PFI-2

🥰Excellent
Catalog No. T1987Alias PFI2, PFI 2, (R)-PFI-2Cas No. 1627676-59-8
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
Pack SizePriceAvailabilityQuantity
5 mg$83In Stock
10 mg$131In Stock
25 mg$254In Stock
50 mg$448In Stock
100 mg$807In Stock
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Product Introduction

Bioactivity
Description
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
Targets&IC50
SETD7:2 nM
In vivo
In the cellular environment, through direct interaction with SETD7, PFI-2 affects Yes-associated protein localization in Hippo pathway signaling and the putative phenotype Setd7 gene deletion. The inhibitory activity of (R)-PFI-2 on human SETD7 was 500-fold higher than that of its isomer, (S)-PFI-2.
AliasPFI2, PFI 2, (R)-PFI-2
Chemical Properties
Molecular Weight499.52
FormulaC23H25F4N3O3S
Cas No.1627676-59-8
SmilesFC1=C2C(=CC(S(N[C@H](CC3=CC(C(F)(F)F)=CC=C3)C(=O)N4CCCC4)(=O)=O)=C1)CCNC2
Relative Density.1.371 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 66 mg/mL (132.12 mM), Heating is recommended.
DMSO: >10 mM
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.0019 mL10.0096 mL20.0192 mL100.0961 mL
5 mM0.4004 mL2.0019 mL4.0038 mL20.0192 mL
10 mM0.2002 mL1.0010 mL2.0019 mL10.0096 mL
Ethanol
1mg5mg10mg50mg
20 mM0.1001 mL0.5005 mL1.0010 mL5.0048 mL
50 mM0.0400 mL0.2002 mL0.4004 mL2.0019 mL
100 mM0.0200 mL0.1001 mL0.2002 mL1.0010 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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