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PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $83 | In Stock | |
10 mg | $131 | In Stock | |
25 mg | $254 | In Stock | |
50 mg | $448 | In Stock | |
100 mg | $807 | In Stock |
Description | PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. |
Targets&IC50 | SETD7:2 nM |
In vivo | In the cellular environment, through direct interaction with SETD7, PFI-2 affects Yes-associated protein localization in Hippo pathway signaling and the putative phenotype Setd7 gene deletion. The inhibitory activity of (R)-PFI-2 on human SETD7 was 500-fold higher than that of its isomer, (S)-PFI-2. |
Alias | PFI2, PFI 2, (R)-PFI-2 |
Molecular Weight | 499.52 |
Formula | C23H25F4N3O3S |
Cas No. | 1627676-59-8 |
Smiles | FC1=C2C(=CC(S(N[C@H](CC3=CC(C(F)(F)F)=CC=C3)C(=O)N4CCCC4)(=O)=O)=C1)CCNC2 |
Relative Density. | 1.371 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 66 mg/mL (132.12 mM), Heating is recommended. DMSO: >10 mM | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
Ethanol
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