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PI4KIII beta inhibitor 3

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PI4KIII beta inhibitor 3

Catalog No. T12467Cas No. 1245319-54-3

PI4KIII beta inhibitor 3 is a novel, highly effective inhibitor of PI4KIIIβ with an IC50 of 5.7 nM.

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Pack Size	Price	Availability	Quantity
500 μg	$253	35 days
1 mg	$480	35 days

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Product Introduction

Bioactivity

Description	PI4KIII beta inhibitor 3 is a novel, highly effective inhibitor of PI4KIIIβ with an IC50 of 5.7 nM.
Targets&IC50	PI4KIIIβ:5.7 nM
In vitro	PI4KIII beta inhibitor 3 is a potent PI4KIII inhibitor with an IC50 of 5.7 nM. It exhibits significant immunosuppressive activity in the mixed lymphocyte reaction (MLR) assay with an IC50 of 3 nM and inhibits IL2 and IFNγ secretion with IC50 values of less than 1 nM, demonstrating effectiveness comparable to cyclosporine A, whose IC50 values for IFNγ and IL2 release are 2 nM and less than 1 nM, respectively [1].
In vivo	Oral administration of PI4KIII beta inhibitor 3 results in prolonged graft survival in 3 out of 6 grafts in each group at day 30. Several grafts continued beating after withdrawal of the treatment (up to 60 days), indicating the induction of a certain type of graft tolerance. To evaluate the operational tolerance phenotype, animals with functional graft at day 60 are challenged with a second graft from the same donor strain or from a third party.

Chemical Properties

Molecular Weight	446.53
Formula	C22H22N8OS
Cas No.	1245319-54-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 20 mg/mL (44.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2395 mL	11.1975 mL	22.3949 mL	111.9746 mL
5 mM	0.4479 mL	2.2395 mL	4.4790 mL	22.3949 mL
10 mM	0.2239 mL	1.1197 mL	2.2395 mL	11.1975 mL
20 mM	0.1120 mL	0.5599 mL	1.1197 mL	5.5987 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc