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PI4KIII beta inhibitor 3
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Catalog No. T12467Cas No. 1245319-54-3
PI4KIII beta inhibitor 3 is a novel, highly effective inhibitor of PI4KIIIβ with an IC50 of 5.7 nM.
PI4KIII beta inhibitor 3
😃Good
Catalog No. T12467Cas No. 1245319-54-3
PI4KIII beta inhibitor 3 is a novel, highly effective inhibitor of PI4KIIIβ with an IC50 of 5.7 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $253 | 35 days | |
| 1 mg | $480 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PI4KIII beta inhibitor 3 is a novel, highly effective inhibitor of PI4KIIIβ with an IC50 of 5.7 nM. |
| Targets&IC50 | PI4KIIIβ:5.7 nM |
| In vitro | PI4KIII beta inhibitor 3 is a potent PI4KIII inhibitor with an IC50 of 5.7 nM. It exhibits significant immunosuppressive activity in the mixed lymphocyte reaction (MLR) assay with an IC50 of 3 nM and inhibits IL2 and IFNγ secretion with IC50 values of less than 1 nM, demonstrating effectiveness comparable to cyclosporine A, whose IC50 values for IFNγ and IL2 release are 2 nM and less than 1 nM, respectively [1]. |
| In vivo | Oral administration of PI4KIII beta inhibitor 3 results in prolonged graft survival in 3 out of 6 grafts in each group at day 30. Several grafts continued beating after withdrawal of the treatment (up to 60 days), indicating the induction of a certain type of graft tolerance. To evaluate the operational tolerance phenotype, animals with functional graft at day 60 are challenged with a second graft from the same donor strain or from a third party. |
| Molecular Weight | 446.53 |
| Formula | C22H22N8OS |
| Cas No. | 1245319-54-3 |
| Relative Density. | 1.432 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (44.79 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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