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PPM-3
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Catalog No. T78901
PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM. While not directly inhibiting tumor cell growth, PPM-3 affects tumor progression through influencing macrophage differentiation [1].
PPM-3
PPM-3
😃Good
Catalog No. T78901
PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM. While not directly inhibiting tumor cell growth, PPM-3 affects tumor progression through influencing macrophage differentiation [1].
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Product Introduction
Bioactivity
Chemical Properties
| Description | PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM. While not directly inhibiting tumor cell growth, PPM-3 affects tumor progression through influencing macrophage differentiation [1]. |
| Targets&IC50 | ERK5:62.4 nM |
| In vitro | PPM-3, applied at a concentration of 200 nM for 0-72 hours to A375 cells, initiates ERK5 degradation within 2-4 hours, with peak degradation observed at 12 hours and sustained for at least 72 hours [1]. Additionally, PPM-3, ranging from 0-1 μM for 12 hours, exhibits ERK5 degradation activity in various cancer cell lines—H1975, HepG2, MDA-MB-231, PC-3, HCT116, and A375—with respective DC50 values of 11.5±2.5, 13.7±8.2, 22.7±13.3, 23.5±10.3, 5.6±1.9, and 41.4±22.3 nM [1]. |
| Molecular Weight | 1000.26 |
| Formula | C54H69N11O6S |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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