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PROTAC BET degrader-2
Catalog No. T12559Cas No. 2093388-33-9
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins, with an IC50 of 9.6 nM.
PROTAC BET degrader-2
Catalog No. T12559Cas No. 2093388-33-9
PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins, with an IC50 of 9.6 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $398 | Backorder | |
| 10 mg | $631 | Backorder | |
| 25 mg | $1,170 | Backorder | |
| 50 mg | Inquiry | Backorder | |
| 100 mg | Inquiry | Backorder | |
| 1 mL x 10 mM (in DMSO) | $637 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins, with an IC50 of 9.6 nM. |
| Targets&IC50 | BET (RS4;11 cells):9.6 nM |
| In vitro | PROTAC BET degrader-2 is a highly potent Bromodomain and Extra-Terminal (BET) proteins degrader (IC50 value of 9.6 nM in cell growth inhibition in the RS4);11 cells and capable of achieving tumor regression[1]. |
| Molecular Weight | 770.84 |
| Formula | C41H42N10O6 |
| Cas No. | 2093388-33-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (64.86 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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