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PROTAC FKBP Degrader-3
😃Good
Catalog No. T18610Cas No. 2079056-43-0
PROTAC FKBP Degrader-3 is a potent FKBP degrader, consisting of a FKBP ligand binding group, a linker, and a VHL binding group [1].
PROTAC FKBP Degrader-3
😃Good
Catalog No. T18610Cas No. 2079056-43-0
PROTAC FKBP Degrader-3 is a potent FKBP degrader, consisting of a FKBP ligand binding group, a linker, and a VHL binding group [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $493 | 10-14 weeks | |
| 5 mg | $993 | 10-14 weeks | |
| 10 mg | $1,490 | 10-14 weeks | |
| 25 mg | $2,190 | 10-14 weeks | |
| 50 mg | $2,980 | 10-14 weeks | |
| 100 mg | $3,950 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC FKBP Degrader-3 is a potent FKBP degrader, consisting of a FKBP ligand binding group, a linker, and a VHL binding group [1]. |
| In vitro | Treatment with 250 nM of PROTAC FKBP Degrader-3 (compound 10) notably enhanced the polyubiquitination of EGFP-FKBP within the first hour, indicating its efficacy in promoting VHL-related protein degradation. This process involves the recruitment of endogenous VHL by PROTAC FKBP Degrader-3 (compound 10), during which ubiquitination was observed specifically at one background lysine residue (Lys158) of EGFP[1]. |
| Molecular Weight | 1295.54 |
| Formula | C68H90N6O17S |
| Cas No. | 2079056-43-0 |
| Relative Density. | 1.233 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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