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PROTAC BRD4 Degrader-16
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Catalog No. T78647Cas No. 2585561-36-8
PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, with IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2). It significantly reduces Cyclin B1 expression, impedes G2/M phase progression, and induces apoptosis in MV-4-11 cells [1].
PROTAC BRD4 Degrader-16
😃Good
Catalog No. T78647Cas No. 2585561-36-8
PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, with IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2). It significantly reduces Cyclin B1 expression, impedes G2/M phase progression, and induces apoptosis in MV-4-11 cells [1].
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, with IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2). It significantly reduces Cyclin B1 expression, impedes G2/M phase progression, and induces apoptosis in MV-4-11 cells [1]. |
| In vitro | PROTAC BRD4 Degrader-16 (compound 7f) (100 nM) significantly induced the degradation of both BRD4 L and BRD4 S in MV-4-11 cells after 4 hours, with BRD4 S levels returning to baseline by 24 hours, similar to dBET6 [1]. |
| Molecular Weight | 819.86 |
| Formula | C46H41N7O8 |
| Cas No. | 2585561-36-8 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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