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PROTAC CDK9 degrader-5
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Catalog No. T74851Cas No. 2935587-89-4
PROTAC CDK9 degrader-5 is a selective PROTAC that mediates degradation of CDK9 via the proteasome pathway, efficiently degrading CDK9 42 and CDK9 55 isoforms with DC50 values of 0.10 μM and 0.14 μM, respectively [1].
PROTAC CDK9 degrader-5
😃Good
Catalog No. T74851Cas No. 2935587-89-4
PROTAC CDK9 degrader-5 is a selective PROTAC that mediates degradation of CDK9 via the proteasome pathway, efficiently degrading CDK9 42 and CDK9 55 isoforms with DC50 values of 0.10 μM and 0.14 μM, respectively [1].
| Pack Size | Price | Availability | Quantity |
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| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC CDK9 degrader-5 is a selective PROTAC that mediates degradation of CDK9 via the proteasome pathway, efficiently degrading CDK9 42 and CDK9 55 isoforms with DC50 values of 0.10 μM and 0.14 μM, respectively [1]. |
| Targets&IC50 | CDK9 42:0.10 μM (DC50), CDK9 55:0.14 μM (DC50) |
| In vitro | PROTAC CDK9 degrader-5 (Compound 15e) at 1μM for a duration of 6 hours reduces the protein levels of MCL2 and competitively degrades CDK9 in MV411 cells [1]. Additionally, administration of PROTAC CDK9 degrader-5 at the same concentration demonstrates a time-dependent decrease in the protein levels of both MCL2 and CDK9, with sustained inhibition observed for up to 24 hours [1]. |
| Molecular Weight | 879.78 |
| Formula | C42H48Cl2N8O9 |
| Cas No. | 2935587-89-4 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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