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PROTAC IRAK4 degrader-3
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Catalog No. T39920Cas No. 2374122-43-5
Alias PROTAC IRAK4 degrader-3
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau (VHL).
PROTAC IRAK4 degrader-3
😃Good
Catalog No. T39920Alias PROTAC IRAK4 degrader-3Cas No. 2374122-43-5
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau (VHL).
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau (VHL). |
| In vitro | PROTAC IRAK4 degrader-3, within a concentration range of 0.01 to 10 μM over 2 hours in PBMCs, induces proteasome-dependent degradation. An increased dosage range up to 100 μM for 18 hours in the same cell type effectively inhibits IL-6 secretion. Western Blot Analysis further confirms that the degradation of IRAK4 by PROTAC occurs in a proteasome-dependent manner within the tested concentration and time frame[1]. |
| Alias | PROTAC IRAK4 degrader-3 |
| Molecular Weight | 1086.3 |
| Formula | C57H68FN11O8S |
| Cas No. | 2374122-43-5 |
| Relative Density. | 1.40 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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