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PROTAC MEK1 Degrader-1
😃Good
Catalog No. T79144Cas No. 2671004-41-2
PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2 phosphorylation. With a pIC50 value of 7.0, it exhibits antiproliferative activity against A375 cells [1].
PROTAC MEK1 Degrader-1
😃Good
Catalog No. T79144Cas No. 2671004-41-2
PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2 phosphorylation. With a pIC50 value of 7.0, it exhibits antiproliferative activity against A375 cells [1].
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Product Introduction
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Chemical Properties
| Description | PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2 phosphorylation. With a pIC50 value of 7.0, it exhibits antiproliferative activity against A375 cells [1]. |
| In vitro | PROTAC MEK1 Degrader-1 (Compound 3) induces MEK1 degradation at concentrations of 1 μM and 10 μM over 12 hours, while lower concentrations increase MEK1 and ERK1/2 expression [1]. At 10 μM, it significantly inhibits IL6 secretion over 12 hours and shows anti-proliferative activity against A375 cells from 0 to 72 hours [1]. Significant MEK and ERK1/2 degradation occurs at 5 hours post-treatment with 10 μM, with complete inhibition at 8 hours [1]. |
| Molecular Weight | 1201.17 |
| Formula | C53H66FIN8O11S2 |
| Cas No. | 2671004-41-2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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