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PROTAC RIPK degrader-6
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Catalog No. T36243Cas No. 2089205-64-9
PROTAC RIPK degrader-6 (example 1) is a PROTAC engineered for RIP Kinase degradation, comprising a RIP2 kinase inhibitor linked to a cereblon binder[1].
PROTAC RIPK degrader-6
😃Good
Catalog No. T36243Cas No. 2089205-64-9
PROTAC RIPK degrader-6 (example 1) is a PROTAC engineered for RIP Kinase degradation, comprising a RIP2 kinase inhibitor linked to a cereblon binder[1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $481 | Backorder | |
| 10 mg | $698 | Backorder | |
| 25 mg | $1,280 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $770 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PROTAC RIPK degrader-6 (example 1) is a PROTAC engineered for RIP Kinase degradation, comprising a RIP2 kinase inhibitor linked to a cereblon binder[1]. |
| In vitro | PROTACs facilitate the targeted degradation of proteins and polypeptides by binding to cereblon at one end and the target protein (RIP2 kinase) at the other, thereby bringing the target protein close to the E3-Ligase. This interaction forms a ternary complex that results in the polyubiquitination and subsequent degradation of the target protein[1]. |
| Molecular Weight | 889.01 |
| Formula | C43H48N6O11S2 |
| Cas No. | 2089205-64-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (112.49 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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