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PROTAC α-synuclein degrader 5
😃Good
Catalog No. T79250Cas No. 2781922-42-5
PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound targeting and degrading α-synuclein aggregates, with a DC50 value of 7.51 μM and a maximum degradation rate (Dmax) of 89%. It incorporates the probe molecule sery308 and E3 ligase ligands, suitable for neurological disease research [1].
PROTAC α-synuclein degrader 5
😃Good
Catalog No. T79250Cas No. 2781922-42-5
PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound targeting and degrading α-synuclein aggregates, with a DC50 value of 7.51 μM and a maximum degradation rate (Dmax) of 89%. It incorporates the probe molecule sery308 and E3 ligase ligands, suitable for neurological disease research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $987 | 35 days |
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Product Introduction
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Chemical Properties
| Description | PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound targeting and degrading α-synuclein aggregates, with a DC50 value of 7.51 μM and a maximum degradation rate (Dmax) of 89%. It incorporates the probe molecule sery308 and E3 ligase ligands, suitable for neurological disease research [1]. |
| In vitro | PROTAC α-synuclein degrader 5 (Compound 2b) administered at concentrations ranging from 0 to 40 μM over a 48-hour period reduced α-synuclein aggregates in a cell model inoculated with PFF [1]. At concentrations from 0 to 10 μM for 48 hours, it decreased α-synuclein aggregates dose-dependently, reducing the number and density of α-synuclein positive spots, along with a gradual decline in fluorescence intensity [1]. |
| Molecular Weight | 767.78 |
| Formula | C39H41N7O10 |
| Cas No. | 2781922-42-5 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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