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Description | PS10 is a ATP-competitive inhibitor of pan-PDK(PDK2, PDK4, PDK1, and PDK3 with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM , respectively). |
Targets&IC50 | PDK1:21.3 μM , PDK3:2.1 μM , PDK2:0.8 μM , PDK4:0.76 μM |
In vivo | PS10, inhibits all four PDK isoforms with IC50 = 0.8 μM for PDK2.?The administration of PS10 (70 mg/kg) to diet-induced obese mice significantly augments pyruvate dehydrogenase complex activity with reduced phosphorylation in different tissues.?Prolonged PS10 treatments result in improved glucose tolerance and notably lessened hepatic steatosis in the mouse model. |
Molecular Weight | 323.32 |
Formula | C14H13NO6S |
Cas No. | 1564265-82-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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