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PS10
🥰Excellent
Catalog No. T12566Cas No. 1564265-82-2
Alias PS 10
PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2, PDK4, PDK1, and PDK3. It significantly increases pyruvate dehydrogenase complex activity, and is used in research on obesity and type 2 diabetes.
PS10
🥰Excellent
Purity: 99.01%
Catalog No. T12566Alias PS 10Cas No. 1564265-82-2
PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2, PDK4, PDK1, and PDK3. It significantly increases pyruvate dehydrogenase complex activity, and is used in research on obesity and type 2 diabetes.
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Purity:99.01%
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Product Introduction
Bioactivity
Chemical Properties
| Description | PS10 is a broad-spectrum PDK inhibitor that inhibits PDK2, PDK4, PDK1, and PDK3. It significantly increases pyruvate dehydrogenase complex activity, and is used in research on obesity and type 2 diabetes. |
| Targets&IC50 | PDK2:0.8 μM, PDK3:2.1 μM, PDK4:0.76 μM, PDK1:21.3 μM |
| In vitro | PS10 is a pan-PDK inhibitor with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1 and PDK3, respectively. The Kd value combined with PDK2 is 239 nM. [1] |
| In vivo | PS10 (70 mg/kg/ day for 3 days) stimulated PDC activity in DIO mice, increased glucose tolerance and reduced hepatic steatosis in DIO mice. [1] PS10 (70 mg/kg/ day, 4 weeks, intraperitoneal injection), mice showed significant improvements in glucose, insulin, and pyruvate tolerance, lower plasma insulin levels, and increased liver insulin signaling. [2] |
| Alias | PS 10 |
| Molecular Weight | 323.32 |
| Formula | C14H13NO6S |
| Cas No. | 1564265-82-2 |
| Smiles | O=S(=O)(C1=CC=C(O)C=C1O)N2CC=3C=C(O)C=C(O)C3C2 |
| Relative Density. | 1.696 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (154.65 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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