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Pyridoclax
😃Good
Catalog No. T16694Cas No. 1651890-44-6
Alias MR-29072
Pyridoclax is an inhibitor of potential Mcl-1.
Pyridoclax
😃Good
Catalog No. T16694Alias MR-29072Cas No. 1651890-44-6
Pyridoclax is an inhibitor of potential Mcl-1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $82 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Pyridoclax is an inhibitor of potential Mcl-1. |
| In vitro | Pyridoclax directly binds to Mcl-1. Pyridoclax induces apoptosis in combination with Bcl-xL-targeting siRNA or with ABT-737 in ovarian, lung, and mesothelioma cancer cells. Pyridoclax causes apoptosis in ovarian, and also in lung, and mesothelioma cancer cells when it is administrated in combination with Bcl-xL-targeting siRNA or Bcl-xL targeting molecules such as ABT-737 or its orally available derivative ABT-263. Pyridoclax sensitizes ovarian carcinoma cells to Bcl-xL-targeting strategies [1][2]. |
| Alias | MR-29072 |
| Molecular Weight | 426.51 |
| Formula | C29H22N4 |
| Cas No. | 1651890-44-6 |
| Relative Density. | 1.192 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (46.89 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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