Shopping Cart

Remove All

Your shopping cart is currently empty

QC6352

Catalog No. T16700Cas No. 1851373-36-8

QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
25 mg	$1,520	8-10 weeks
50 mg	$1,980	8-10 weeks
100 mg	$2,500	8-10 weeks
1 mL x 10 mM (in DMSO)	$434	8-10 weeks

Bulk & Custom

Add to Cart

Questions

Product Introduction

Bioactivity

Description	QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).
In vitro	QC6352 is an effective KDM4C inhibitor (IC50: 35±8 nM). QC6352 blocks the proliferation and self-renewal of BCSCs. In a concentration-dependent manner QC6352 dramatically decreases the anchorage-independent sphere-forming capacity of BCSC1 and BCSC2. The protein levels of (Epidermal growth factor receptor) EGFR are reduced in both BCSC1 and BCSC2 upon treatment with QC6352 [1][2].
In vivo	QC6352 strongly affects tumor growth and the final tumor weight of both BCSC1 and BCSC2 xenografts. QC6352 treatment is well tolerated and does not affect body weight of the mice. Treatment with the KDM4 inhibitor QC6352 blocks BCSC xenograft tumor growth[2].

Chemical Properties

Molecular Weight	387.47
Formula	C24H25N3O2
Cas No.	1851373-36-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (64.52 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5808 mL	12.9042 mL	25.8084 mL	129.0422 mL
5 mM	0.5162 mL	2.5808 mL	5.1617 mL	25.8084 mL
10 mM	0.2581 mL	1.2904 mL	2.5808 mL	12.9042 mL
20 mM	0.1290 mL	0.6452 mL	1.2904 mL	6.4521 mL
50 mM	0.0516 mL	0.2581 mL	0.5162 mL	2.5808 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc