Shopping Cart
- Remove All
Your shopping cart is currently empty
QC6352
😃Good
Catalog No. T16700Cas No. 1851373-36-8
QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).
QC6352
😃Good
Catalog No. T16700Cas No. 1851373-36-8
QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 8-10 weeks | |
| 50 mg | $1,980 | 8-10 weeks | |
| 100 mg | $2,500 | 8-10 weeks | |
| 1 mL x 10 mM (in DMSO) | $434 | 8-10 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "QC6352"
Procaine
Vitamin H3, Spinocaine, Novocaine, Duracaine
T002959-46-1
Procaine (Vitamin H3) is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.
- $30
Size
QTY
Procaine hydrochloride
Procaine HCl, Novocaine HCl
T080251-05-8
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.
- $31
Size
QTY
Daminozide
Succinic Acid, DMASA, Aminozide
T37191596-84-5
Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.
- $42
Size
QTY
FY-21
T77583In house
FY-21 is a selective LSD1 inhibitor (IC50= 340 nM) that inhibits proliferation and colony formation of leukemia cells, decreases mRNA levels of the transcription factors HOXA9 and MEIS1, and can be used in the study of leukemia.
- $195
Size
QTY
AS8351
Cited
NSC51355, AS-8351, AS 8351
T4100796-42-9
AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.
- $43
Size
QTY
CitedLSD1-IN-24
T678714734-59-2
LSD1-IN-24 is a selective and potent LSD1 inhibitor with an IC50 value of 0.247 μM.LSD1-IN-24 induces PD-L1 expression and enhances the T cell killing response, and can be used in cancer-related diseases.
- $52
Size
QTY
GSK-J4 Cited
GSK J4
T31001373423-53-0In house
GSK-J4 (GSK J4 HCl) is a cell permeable prodrug of GSK-J1, a dual inhibitor of the H3K27me3/me2 demethylases JMJD3/KDM6B and UTX/KDM6A (IC50=8.6/6.6 μM). GSK-J4 induces endoplasmic reticulum stress-related apoptosis.
- $51
Size
QTY
CitedTranylcypromine (2-PCPA) hydrochloride
Tranylcypromine (2-PCPA) HCl, SKF-385 HCl
T10251986-47-6
Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl), a Monoamine Oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and atypical depression.
- $39
Size
QTY
Eicosapentaenoic Acid
T536810417-94-4
Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms.
- $68
Size
QTY
Tranylcypromine hemisulfate Cited
Tranylcypromine Sulfate, Tranylcypromine (hemisulfate)
T794213492-01-8
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.
- $48
Size
QTY
CitedGSK-LSD1 dihydrochloride
GSK-LSD1 2HCl, GSK-LSD1 (hydrochloride)
T23152102933-95-7
GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, MAO-B).
- $34
Size
QTY
Zavondemstat
TACH 101 free base, QC8222 free base
T701211851412-93-5In house
Zavondemstat (QC8222 free base) is a histone lysine demethylase 4 (KDM4) inhibitor with anticancer and antitumor activity for the study of triple-negative and breast cancers.
- $152
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM). |
| Targets&IC50 | KDM4C:35 nM |
| In vitro | QC6352 is an effective KDM4C inhibitor (IC50: 35±8 nM). QC6352 blocks the proliferation and self-renewal of BCSCs. In a concentration-dependent manner QC6352 dramatically decreases the anchorage-independent sphere-forming capacity of BCSC1 and BCSC2. The protein levels of (Epidermal growth factor receptor) EGFR are reduced in both BCSC1 and BCSC2 upon treatment with QC6352 [1][2]. |
| In vivo | QC6352 significantly inhibits tumor growth and final tumor weight in both BCSC1 and BCSC2 xenografts. The treatment is well tolerated, with no impact on mice body weight. Administration of the KDM4 inhibitor QC6352 effectively blocks BCSC xenograft tumor growth [2]. |
| Molecular Weight | 387.47 |
| Formula | C24H25N3O2 |
| Cas No. | 1851373-36-8 |
| Relative Density. | 1.243 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (64.52 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy QC6352 | purchase QC6352 | QC6352 cost | order QC6352 | QC6352 chemical structure | QC6352 in vivo | QC6352 in vitro | QC6352 formula | QC6352 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.