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Ripisartan

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Purity:98.24%

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COA HNMR HPLC LCMS

Ripisartan

Catalog No. T28540Cas No. 148504-51-2

Ripisartan (UP-269-6) is a potent and specific angiotensin II receptor antagonist that inhibits angiotensin II-mediated sympathetic tachycardia responses.

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Pack Size	Price	Availability
1 mg	$191	In Stock
5 mg	$470	In Stock
10 mg	$689	In Stock
25 mg	$1,080	In Stock
50 mg	$1,460	In Stock
100 mg	$1,960	In Stock
500 mg	$3,930	In Stock

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Product Introduction

Bioactivity

Description	Ripisartan (UP-269-6) is a potent and specific angiotensin II receptor antagonist that inhibits angiotensin II-mediated sympathetic tachycardia responses.
In vitro	UP 269-6 bound selectively to AT1 receptors as evidenced by the inhibition of specific [125I] Sar1, Ile8-AII binding in rat adrenal membranes (IC50 = 35.8 nM) and in cultured vascular smooth muscle cells (IC50 = 23.8 nM). UP 269-6 displayed a very high selectivity for the AT1 compared to the AT2 receptor subtype (IC50 >10,000 nM). UP 269-6 inhibited the AII-induced contraction of isolated rabbit aortic strips.[4] UP 269-6 at low concentrations (10(-10), 3 x 10(-10), 10(-9) M) of UP 269-6 and insurmountable antagonism at higher concentrations (3 x 10(-9), 10(-8), 3 x 10(-8) M). Based on the calculated pA2 values, UP 269-6 (9.86 +/- 0.25) was an angiotensin II receptor antagonist as potent as L-158,809 (9.82 +/- 0.37) and much more potent than losartan (7.96 +/- 0.38). UP 269-6 was devoid of affinity (IC50 > 10,000 nM) for many other receptors, ion channels and uptake sites, demonstrating its high specificity for AII receptors. Furthermore, this compound did not affect the contractile response to KCl or phenylephrine in rabbit aorta and exhibited no effect on angiotensin-converting enzyme activity. These data demonstrate that UP 269-6 is a highly potent, selective, and specific AT1 receptor antagonist.[4]
In vivo	UP 269-6 (0.03-1 mg/kg; i.v.; rats) shifted dose-dependently to the right of the dose-pressor response curve for angiotensin II and decreased the maximum response. UP 269-6 antagonized the angiotensin II sympathetic-mediated tachycardiac response.[1] UP 269-6 inhibited dose-dependently the pressor response to angiotensin II with an ID50 of 4.5 micrograms/kg, i.v. in conscious normotensive dogs.[1] UP 269-6 (0.1 to 30 mg/kg; Oral) resulted in a dose-dependent and long-lasting inhibition of the angiotensin II-induced pressor response in conscious normotensive rats and dogs.[1] UP 269-6 is a potent and specific angiotensin II receptor antagonist and does not possess agonistic properties.
Alias	UP 269-6, UP-2696, UP 2696, UP-269-6, UP269-6

Chemical Properties

Molecular Weight	426.47
Formula	C23H22N8O
Cas No.	148504-51-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (128.97 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3448 mL	11.7242 mL	23.4483 mL	117.2415 mL
5 mM	0.4690 mL	2.3448 mL	4.6897 mL	23.4483 mL
10 mM	0.2345 mL	1.1724 mL	2.3448 mL	11.7242 mL
20 mM	0.1172 mL	0.5862 mL	1.1724 mL	5.8621 mL
50 mM	0.0469 mL	0.2345 mL	0.4690 mL	2.3448 mL
100 mM	0.0234 mL	0.1172 mL	0.2345 mL	1.1724 mL

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