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RNA polymerase II-IN-1
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Catalog No. T74630Cas No. 2891451-07-1
RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM and exhibits heightened cytotoxicity towards cancer cells while reducing toxicity in normal cells compared to α-Amanitin [1].
RNA polymerase II-IN-1
😃Good
Catalog No. T74630Cas No. 2891451-07-1
RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM and exhibits heightened cytotoxicity towards cancer cells while reducing toxicity in normal cells compared to α-Amanitin [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM and exhibits heightened cytotoxicity towards cancer cells while reducing toxicity in normal cells compared to α-Amanitin [1]. |
| In vitro | RNA polymerase II-IN-1 (compound 19iv) demonstrates cytotoxic effects on CHO, HEK293, and HeLa cell lines, exhibiting IC50 values of 0.19 μM, 0.20 μM, and 3.32 μM, respectively. Compared to α-Amanitin, it shows reduced toxicity in HepG2 cells, with an IC50 of 5.6 μM, which is 2.7-fold lower [1]. |
| Molecular Weight | 887.96 |
| Formula | C38H53N11O12S |
| Cas No. | 2891451-07-1 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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