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Ro 67-4853 is a selective mGluR1 positive allosteric modulator, enhancing the response to the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) in anesthetized rats through iontophoretic administration.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $78 | In Stock | |
5 mg | $153 | In Stock | |
10 mg | $223 | In Stock | |
25 mg | $377 | In Stock | |
50 mg | $558 | In Stock | |
100 mg | $788 | In Stock | |
200 mg | $1,120 | In Stock |
Description | Ro 67-4853 is a selective mGluR1 positive allosteric modulator, enhancing the response to the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) in anesthetized rats through iontophoretic administration. |
Targets&IC50 | mGluR1a:7.16 (PEC50) |
In vitro | Ro 67-4853 (1 μM) was preincubated with BHK cells stably expressing mGluR1a for 10 min before the addition of a range of glutamate concentrations. These compounds had no agonist activity at mGluR1 when added alone, but the concentration-response curve for glutamate was shifted to the left approximately 15-fold.[1] |
Alias | Ro67-4853, Ro 674853 |
Molecular Weight | 325.36 |
Formula | C19H19NO4 |
Cas No. | 302841-89-0 |
Smiles | O=C(OCCCC)NC(=O)C1C=2C=CC=CC2OC=3C=CC=CC31 |
Relative Density. | 1.31g/cm3 |
Storage | store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMF: 10 mg/mL (30.74 mM), Sonication is recommended. DMSO: 8 mg/mL (24.59 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO/DMF
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