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Ro 67-4853
🥰Excellent
Catalog No. T23248Cas No. 302841-89-0
Alias Ro67-4853, Ro 674853
Ro 67-4853 is a selective mGluR1 positive allosteric modulator, enhancing the response to the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) in anesthetized rats through iontophoretic administration.
Ro 67-4853
🥰Excellent
Purity: 98.57%
Catalog No. T23248Alias Ro67-4853, Ro 674853Cas No. 302841-89-0
Ro 67-4853 is a selective mGluR1 positive allosteric modulator, enhancing the response to the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) in anesthetized rats through iontophoretic administration.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $59 | In Stock | |
| 5 mg | $142 | In Stock | |
| 10 mg | $208 | In Stock | |
| 25 mg | $356 | In Stock | |
| 50 mg | $527 | In Stock | |
| 100 mg | $749 | In Stock | |
| 200 mg | $987 | In Stock |
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Purity:98.57%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ro 67-4853 is a selective mGluR1 positive allosteric modulator, enhancing the response to the agonist (S)-3,5-dihydroxyphenylglycine (DHPG) in anesthetized rats through iontophoretic administration. |
| Targets&IC50 | mGluR1a:7.16 (PEC50) |
| In vitro | Ro 67-4853 (1 μM) was preincubated with BHK cells stably expressing mGluR1a for 10 min before the addition of a range of glutamate concentrations. These compounds had no agonist activity at mGluR1 when added alone, but the concentration-response curve for glutamate was shifted to the left approximately 15-fold.[1] |
| Alias | Ro67-4853, Ro 674853 |
| Molecular Weight | 325.36 |
| Formula | C19H19NO4 |
| Cas No. | 302841-89-0 |
| Smiles | O=C(OCCCC)NC(=O)C1C=2C=CC=CC2OC=3C=CC=CC31 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMF: 10 mg/mL (30.74 mM), Sonication is recommended. DMSO: 8 mg/mL (24.59 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO/DMF
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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