Shopping Cart
- Remove All
Your shopping cart is currently empty
RTI-13951-33
Catalog No. T12778LCas No. 2244884-08-8
RTI-13951-33 is an effective and brain-penetrant GPR88 agonist (EC50: 25 nM, in GPR88 cAMP functional assay).
RTI-13951-33
Catalog No. T12778LCas No. 2244884-08-8
RTI-13951-33 is an effective and brain-penetrant GPR88 agonist (EC50: 25 nM, in GPR88 cAMP functional assay).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "RTI-13951-33"
Azathioprine
Cited
BW 57-322
T1237446-86-6
Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.
- $45
Size
QTY
CitedBenzyl nicotinate
Rubriment, Pycaril
T771394-44-0
Benzyl nicotinate (Pycaril) is a agonist of GPR109A receptor and GPR109B receptor
- $29
Size
QTY
Monomethyl fumarate
T120952756-87-8
Monomethyl fumarate is a potent agonist of GPR109A .
- $42
Size
QTY
Vincamine
Perval, Oxybral, Novicet, Equipur, Devincan, Angiopac
T12861617-90-9
Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.
- $40
Size
QTY
TUG-1375 Cited
T77962247372-59-2
TUG-1375 is an Agonist of Thiazolidine Free Fatty Acid Receptor 2
- $135
Size
QTY
CitedQuestiomycin A
T368181916-59-2
Questiomycin A is an antibiotic produced in crème fraiche with antibacterial and anticancer activities. Questiomycin A suppresses expression of GRP78, a cell-protective ER chaperone protein.
- $50
Size
QTY
CRTh2 antagonist 2
T10889780763-95-3In house
CRTh2 antagonist 2 is a selective and potent CRTH2 antagonist, IC50≤10 nM. CRTh2 antagonist 2 can be used to study the direction of androgenic alopecia.
- $109
Size
QTY
1-methoxycyclopropanecarboxylic acid
T9437100683-08-7
1-methoxycyclopropanecarboxylic acid is an agonist of free fatty acid receptor 3 (FFAR3, human).
- $30
Size
QTY
Fezagepras sodium
Setogepram sodium salt, PBI-4050 sodium salt
T123751254472-97-3In house
Fezagepras sodium (Setogepram sodium salt) is an orally active GPR40 agonist and is an antagonist or inverse agonist for GPR84, with anti-fibrotic, anti-inflammatory and anti-proliferative actions.
- $36
Size
QTY
CAY10595
T10691916047-16-0In house
CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM.
- $46
Size
QTY
Timapiprant
OC000459
T2664851723-84-7
Timapiprant (OC000459) is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM).
- $30
Size
QTY
NF-56-EJ40
T122162380230-73-7
NF-56-EJ40 is an effective and highly selective antagonist of human SUCNR1 with an IC50 of 25 nM and a Ki of 33 nM.
- $83
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | RTI-13951-33 is an effective and brain-penetrant GPR88 agonist (EC50: 25 nM, in GPR88 cAMP functional assay). |
| Targets&IC50 | GPR88:(EC50)25 nM |
| In vitro | RTI-13951-33 poorly inhibits SERT (IC50: 25.1 ± 2.7 μM). RTI-13951-33 elevates [35S]-GTPγS binding (EC50: 535 nM) in mouse striatal membranes but not in membranes from GPR88 KO mice. RTI-13951-33 has weak affinities at kappa opioid receptor (KOR; Ki, 2.29 μM), vesicular monoamine transporter (VMAT; Ki, 4.23 μM), and moderate affinity at serotonin transporter (SERT; Ki, 0.75 μM) [1]. |
| In vivo | RTI-13951-33 (10 and 20 mg/kg, i.p.) dose-dependently reduces alcohol lever responses in a rat model of alcohol self-administration. RTI-13951-33 (10 mg/kg, i.p.) has sufficient brain penetration, with t1/2 of 48 min and 87 min in rat plasma and brain [1]. |
| Molecular Weight | 459.58 |
| Formula | C28H33N3O3 |
| Cas No. | 2244884-08-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy RTI-13951-33 | purchase RTI-13951-33 | RTI-13951-33 cost | order RTI-13951-33 | RTI-13951-33 chemical structure | RTI-13951-33 in vivo | RTI-13951-33 in vitro | RTI-13951-33 formula | RTI-13951-33 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.