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RTIOXA-43
🥰Excellent
Catalog No. T87345Cas No. 2832067-72-6
RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulness and attenuates episodic sleep symptoms and is commonly used in studies related to narcolepsy and neural signaling.
RTIOXA-43
🥰Excellent
Catalog No. T87345Cas No. 2832067-72-6
RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulness and attenuates episodic sleep symptoms and is commonly used in studies related to narcolepsy and neural signaling.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $215 | In Stock | |
| 5 mg | $538 | In Stock | |
| 10 mg | $868 | In Stock | |
| 25 mg | $1,730 | In Stock | |
| 50 mg | $2,780 | In Stock | |
| 100 mg | $3,760 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $786 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulness and attenuates episodic sleep symptoms and is commonly used in studies related to narcolepsy and neural signaling. |
| Targets&IC50 | OX1 recepter:24nM (EC50), OX2 recepter:24nM (EC50) |
| In vivo | Methods: Orexin modulation was induced in middle-aged (12 months) mice by peripheral injection of the small molecule orexin receptor agonist RTIOXA-133. Sleep-wake variables were measured by telemetry (after RTIOXA-43). Results: RTIOXA-43 improved wake time, reduced sleep duration (NREM and REM), and sleep/wake fragmentation. In addition, RTIOXA-43 improved sleep/wake quality by both reducing bout number and increasing bout duration. [1] |
| Molecular Weight | 663.79 |
| Formula | C37H37N5O5S |
| Cas No. | 2832067-72-6 |
| Smiles | COc1ccc(cc1S(=O)(=O)Nc1cccc(NCCNC(=O)c2cccc(C)c2)c1)-c1cccc(c1)C(=O)N(C)Cc1ccncc1 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (120.52 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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