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S1g-10
🥰Excellent
Catalog No. T201396Cas No. 3032432-71-3
Alias S1g10
S1g-10 is an Hsp70/Bim inhibitor that exhibits significant antitumor activity, particularly in chronic myeloid leukemia (CML) cells. It inhibits the protein-protein interaction between Hsp70 and Bim, blocking cancer cell survival signals and inducing apoptosis. S1g-10 is an optimized derivative of S1g-2, with a 10-fold increase in anticancer potency.
S1g-10
🥰Excellent
Catalog No. T201396Alias S1g10Cas No. 3032432-71-3
S1g-10 is an Hsp70/Bim inhibitor that exhibits significant antitumor activity, particularly in chronic myeloid leukemia (CML) cells. It inhibits the protein-protein interaction between Hsp70 and Bim, blocking cancer cell survival signals and inducing apoptosis. S1g-10 is an optimized derivative of S1g-2, with a 10-fold increase in anticancer potency.
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Product Introduction
Bioactivity
Chemical Properties
| Description | S1g-10 is an Hsp70/Bim inhibitor that exhibits significant antitumor activity, particularly in chronic myeloid leukemia (CML) cells. It inhibits the protein-protein interaction between Hsp70 and Bim, blocking cancer cell survival signals and inducing apoptosis. S1g-10 is an optimized derivative of S1g-2, with a 10-fold increase in anticancer potency. |
| Alias | S1g10 |
| Molecular Weight | 433.61 |
| Formula | C26H31N3OS |
| Cas No. | 3032432-71-3 |
| Smiles | N#CC=1C(=O)C2=CC=CC3=C(SC4CCCCC4)C=CC(C1NCCN(CC)CC)=C32 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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