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SC 19220

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Catalog No. T23330Cas No. 19395-87-0
Alias SC19220

SC 19220 is a prostaglandin E2 receptor EP1 antagonist.SC 19220 inhibits RANKL-induced osteoclastogenesis by inhibiting the RANK/RANKL signaling pathway in osteoclast precursors.

SC 19220

SC 19220

🥰Excellent
Catalog No. T23330Alias SC19220Cas No. 19395-87-0
SC 19220 is a prostaglandin E2 receptor EP1 antagonist.SC 19220 inhibits RANKL-induced osteoclastogenesis by inhibiting the RANK/RANKL signaling pathway in osteoclast precursors.
Pack SizePriceAvailabilityQuantity
1 mg$49In Stock
5 mg$213In Stock
10 mg$365In Stock
25 mg$786In Stock
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Product Introduction

Bioactivity
Description
SC 19220 is a prostaglandin E2 receptor EP1 antagonist.SC 19220 inhibits RANKL-induced osteoclastogenesis by inhibiting the RANK/RANKL signaling pathway in osteoclast precursors.
In vivo
SC 19220 (5-20 mg/kg, i.v.), a competitive PGE receptor antagonist, enhances bladder capacity and attenuates voiding efficiency when voiding is induced by slow intravesical filling in urethane-anesthetized rats. [1]
AliasSC19220
Chemical Properties
Molecular Weight331.75
FormulaC16H14ClN3O3
Cas No.19395-87-0
SmilesO=C(NNC(=O)C)N1C2=CC(Cl)=CC=C2OC=3C=CC=CC3C1
Relative Density.1.38g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (241.15 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0143 mL15.0716 mL30.1432 mL150.7159 mL
5 mM0.6029 mL3.0143 mL6.0286 mL30.1432 mL
10 mM0.3014 mL1.5072 mL3.0143 mL15.0716 mL
20 mM0.1507 mL0.7536 mL1.5072 mL7.5358 mL
50 mM0.0603 mL0.3014 mL0.6029 mL3.0143 mL
100 mM0.0301 mL0.1507 mL0.3014 mL1.5072 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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