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SC 51089

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Catalog No. T23331Cas No. 146033-02-5
Alias SC 51089 free base

SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's disease R6/1 mouse model .

SC 51089

SC 51089

😃Good
Catalog No. T23331Alias SC 51089 free baseCas No. 146033-02-5
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's disease R6/1 mouse model .
Pack SizePriceAvailabilityQuantity
1 mg$2936-8 weeks
5 mg$7226-8 weeks
10 mg$9876-8 weeks
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's disease R6/1 mouse model .
Targets&IC50
FP:61.1 μM (Ki), EP1:1.3 μM (Ki), 11.2 μM (Ki):EP3, TP:11.2 μM (Ki)
In vivo
In the R6/1 mouse model of Huntington's disease (HD), treatment with SC 51089 (40 μg/kg/day; i.p.) for 28 days improved motor coordination and balance deficits, rescued long-term memory loss, as well as improved the expression of specific synaptic markers and reduced the number of intranuclear inclusions of huntingtin protein in the striatum and hippocampus[3].
AliasSC 51089 free base
Chemical Properties
Molecular Weight459.33
FormulaC22H20Cl2N4O3
Cas No.146033-02-5
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (189.19 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1771 mL10.8854 mL21.7708 mL108.8542 mL
5 mM0.4354 mL2.1771 mL4.3542 mL21.7708 mL
10 mM0.2177 mL1.0885 mL2.1771 mL10.8854 mL
20 mM0.1089 mL0.5443 mL1.0885 mL5.4427 mL
50 mM0.0435 mL0.2177 mL0.4354 mL2.1771 mL
100 mM0.0218 mL0.1089 mL0.2177 mL1.0885 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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