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SC 51089
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Catalog No. T23331Cas No. 146033-02-5
Alias SC 51089 free base
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's disease R6/1 mouse model .
SC 51089
😃Good
Catalog No. T23331Alias SC 51089 free baseCas No. 146033-02-5
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's disease R6/1 mouse model .
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | 6-8 weeks | |
| 5 mg | $722 | 6-8 weeks | |
| 10 mg | $987 | 6-8 weeks | |
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's disease R6/1 mouse model . |
| Targets&IC50 | FP:61.1 μM (Ki), EP1:1.3 μM (Ki), 11.2 μM (Ki):EP3, TP:11.2 μM (Ki) |
| In vivo | In the R6/1 mouse model of Huntington's disease (HD), treatment with SC 51089 (40 μg/kg/day; i.p.) for 28 days improved motor coordination and balance deficits, rescued long-term memory loss, as well as improved the expression of specific synaptic markers and reduced the number of intranuclear inclusions of huntingtin protein in the striatum and hippocampus[3]. |
| Alias | SC 51089 free base |
| Molecular Weight | 459.33 |
| Formula | C22H20Cl2N4O3 |
| Cas No. | 146033-02-5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (189.19 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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