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Sennoside B

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Purity:98.92%

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COA HPLC HNMR

Sennoside B

Catalog No. T2734Cas No. 128-57-4

Sennoside B is an anthranoid. Anthranoid derivatives are used all over the world as a treatment for constipation.

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Pack Size	Price	Availability	Quantity
20 mg	$60	In Stock

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Related Compound Libraries of "Sennoside B"

Product Introduction

Bioactivity

Description	Sennoside B is an anthranoid. Anthranoid derivatives are used all over the world as a treatment for constipation.
In vitro	Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits platelet-derived growth factor (PDGF)-stimulated MG63 cell proliferation by binding to PDGF-BB and its receptor and down-regulating the PDGFR-beta signaling pathway. Pre-incubation of PDGF-BB with sennoside B inhibits the phosphorylation of pathway components including Ak strain transforming protein (AKT), signal transducer and activator of transcription 5 (STAT-5) and extracellular signal-regulated kinase 1/2 (ERK1/2). [2] It also inhibits bovine serum monoamine oxidase with IC50 of 9 μM. [1]
In vivo	LD50: Mice 5000 mg/kg (i.g.); Rats 5000 mg/kg (i.g.). [3]

Chemical Properties

Molecular Weight	862.74
Formula	C42H38O20
Cas No.	128-57-4

Storage & Solubility Information

Storage

keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 91 mg/mL(105.5 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1591 mL	5.7955 mL	11.5910 mL	57.9549 mL
5 mM	0.2318 mL	1.1591 mL	2.3182 mL	11.5910 mL
10 mM	0.1159 mL	0.5795 mL	1.1591 mL	5.7955 mL
20 mM	0.0580 mL	0.2898 mL	0.5795 mL	2.8977 mL
50 mM	0.0232 mL	0.1159 mL	0.2318 mL	1.1591 mL
100 mM	0.0116 mL	0.0580 mL	0.1159 mL	0.5795 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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