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Simlukafusp alfa
🥰Excellent
Catalog No. T77169Cas No. 1776942-10-9
Alias RO6874281, RO 6874281, RG-7461, FAP-IL2v, FAPIL2v, aFAP-IL2v
Simlukafusp alfa (FAP-IL2v) is a tumor-targeting immune cytokine, a human IgG1 antibody, with antitumor activity and immunostimulatory properties that potentiate in vitro and in vivo activity of therapeutic antibodies mediating antibody-dependent or T-cell-independent cytotoxicity (TDCC) and programmed death ligand 1 (PD-L1) checkpoint inhibition.
Simlukafusp alfa
Simlukafusp alfa
🥰Excellent
Catalog No. T77169Alias RO6874281, RO 6874281, RG-7461, FAP-IL2v, FAPIL2v, aFAP-IL2vCas No. 1776942-10-9
Simlukafusp alfa (FAP-IL2v) is a tumor-targeting immune cytokine, a human IgG1 antibody, with antitumor activity and immunostimulatory properties that potentiate in vitro and in vivo activity of therapeutic antibodies mediating antibody-dependent or T-cell-independent cytotoxicity (TDCC) and programmed death ligand 1 (PD-L1) checkpoint inhibition.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 1.415 € | In Stock | |
| 5 mg | 3.600 € | In Stock |
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CitedSelect Batch
Concentration:5.95 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | Simlukafusp alfa (FAP-IL2v) is a tumor-targeting immune cytokine, a human IgG1 antibody, with antitumor activity and immunostimulatory properties that potentiate in vitro and in vivo activity of therapeutic antibodies mediating antibody-dependent or T-cell-independent cytotoxicity (TDCC) and programmed death ligand 1 (PD-L1) checkpoint inhibition. |
| Targets&IC50 | FAP (human):0.3 nM (KD), FAP (cynomolgus monkeys):0.23 nM (KD), IL-2Rβγ (mouse):660 pM (KD), FAP (mouse):0.5 nM (KD), IL-2Rβγ (cynomolgus monkeys):80 pM (KD), IL-2Rβγ (human):43 pM (KD) |
| In vitro | The binding constants of Simlukafusp alfa to IL-2Rβγ and FAP receptors of different species were as follows: huIL-2Rβγ: 43 pM; cyIL-2Rβγ: 80 pM; muIL-2Rβγ: 660 pM; huFAP: 0.3 nM; cyFAP: 0.23 nM; muFAP: 0.5 nM. In in vitro experiments, Simlukafusp alfa (0-100 nM; 5 days of treatment) was able to activate CD4+ and CD8+ T cells as well as NK cells, but did not preferentially activate Tregs. furthermore, Simlukafusp alfa (0-100 nM) potentiated Cetuximab-mediated antibody-dependent cellular cytotoxicity in vitro (ADCC ) and Cibisatamab-mediated T cell-dependent cytotoxicity (TDCC). [1] |
| In vivo | In a mouse model of human cancer, Simlukafusp alfa administered intravenously at a dose of 1 mg/kg once a week for 4 weeks demonstrated significant efficacy when combined with therapeutic antibodies. [1] |
| Alias | RO6874281, RO 6874281, RG-7461, FAP-IL2v, FAPIL2v, aFAP-IL2v |
| Cas No. | 1776942-10-9 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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