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SJ1008030 formic
Catalog No. T77944
SJ1008030 (compound 8) formic is a selective JAK2 degrader from the PROTAC class, exhibiting efficacy in inhibiting MHH-CALL-4 leukemia cell growth with an IC50 of 5.4 nM, and is potentially applicable for leukemia research [1].
SJ1008030 formic
SJ1008030 formic
Catalog No. T77944
SJ1008030 (compound 8) formic is a selective JAK2 degrader from the PROTAC class, exhibiting efficacy in inhibiting MHH-CALL-4 leukemia cell growth with an IC50 of 5.4 nM, and is potentially applicable for leukemia research [1].
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| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SJ1008030 (compound 8) formic is a selective JAK2 degrader from the PROTAC class, exhibiting efficacy in inhibiting MHH-CALL-4 leukemia cell growth with an IC50 of 5.4 nM, and is potentially applicable for leukemia research [1]. |
| In vitro | SJ1008030 (compound 8) demonstrated activity in the CRLF2r cell line (MHH-CALL-4), with an IC50 of 5.4 nM after 72 hours (formic) [1]. SJ1008030 treatment at concentrations ranging from 0-4.3 μM for 72 hours (formic) led to dose-dependent degradation of JAK, GSPT1, and IKZF1 proteins in MHH-CALL-4 cells [1]. Additionally, at concentrations of 0-10 μM over 24 hours (formic), SJ1008030 induced dose-dependent degradation of JAK2 and GSPT1 proteins in xenografted bone marrow cells (SJBALL021415), indicating inhibition of the JAK-STAT signaling pathway [1]. |
| Molecular Weight | 919.96 |
| Formula | C43H45N13O9S |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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