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Pack Size | Price | Availability | Quantity |
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5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | SJ1008030 (compound 8) TFA is a selective JAK2-degrading PROTAC that inhibits the growth of MHH-CALL-4 leukemia cells with an IC50 of 5.4 nM, indicating its potential use for leukemia research [1]. |
In vitro | SJ1008030 (compound 8) exhibited activity in CRLF2r cell line (MHH-CALL-4) with an IC50 of 5.4 nM after 72-hour treatment with TFA [1]. Dose-dependent degradation of JAK, GSPT1, and IKZF1 was observed in MHH-CALL-4 cells treated with SJ1008030 (0-4.3 μM; 72 hours) TFA [1]. Additionally, SJ1008030 (0-10 μM; 24h) TFA dose-dependently degraded JAK2 and GSPT1 proteins in xenografted bone marrow cells SJBALL021415, indicating inhibition of the JAK-STAT signaling pathway [1]. |
Molecular Weight | 987.96 |
Formula | C44H44F3N13O9S |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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