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SJ1008030 TFA
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Catalog No. T77943
SJ1008030 (compound 8) TFA is a selective JAK2-degrading PROTAC that inhibits the growth of MHH-CALL-4 leukemia cells with an IC50 of 5.4 nM, demonstrating its potential for leukemia research [1].
SJ1008030 TFA
SJ1008030 TFA
😃Good
Catalog No. T77943
SJ1008030 (compound 8) TFA is a selective JAK2-degrading PROTAC that inhibits the growth of MHH-CALL-4 leukemia cells with an IC50 of 5.4 nM, demonstrating its potential for leukemia research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SJ1008030 (compound 8) TFA is a selective JAK2-degrading PROTAC that inhibits the growth of MHH-CALL-4 leukemia cells with an IC50 of 5.4 nM, demonstrating its potential for leukemia research [1]. |
| In vitro | SJ1008030 (compound 8) exhibited activity in CRLF2r cell line (MHH-CALL-4) with an IC50 of 5.4 nM after 72-hour treatment with TFA [1]. Dose-dependent degradation of JAK, GSPT1, and IKZF1 was observed in MHH-CALL-4 cells treated with SJ1008030 (0-4.3 μM; 72 hours) TFA [1]. Additionally, SJ1008030 (0-10 μM; 24h) TFA dose-dependently degraded JAK2 and GSPT1 proteins in xenografted bone marrow cells SJBALL021415, indicating inhibition of the JAK-STAT signaling pathway [1]. |
| Molecular Weight | 987.96 |
| Formula | C44H44F3N13O9S |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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