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SJF620 hydrochloride
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Catalog No. T74002Cas No. 2821938-05-8
SJF620 hydrochloride is a PROTAC that utilizes a lenalidomide analog to recruit CRBN and ligands to target Btk, exhibiting a DC50 of 7.9 nM [1].
SJF620 hydrochloride
😃Good
Catalog No. T74002Cas No. 2821938-05-8
SJF620 hydrochloride is a PROTAC that utilizes a lenalidomide analog to recruit CRBN and ligands to target Btk, exhibiting a DC50 of 7.9 nM [1].
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Product Introduction
Bioactivity
Chemical Properties
| Description | SJF620 hydrochloride is a PROTAC that utilizes a lenalidomide analog to recruit CRBN and ligands to target Btk, exhibiting a DC50 of 7.9 nM [1]. |
| In vitro | SJF620 hydrochloride functions as a proteolysis-targeting chimera (PROTAC), effectively inducing the degradation of Bruton’s tyrosine kinase (BTK) in cellular assays. It achieves this with a degradation concentration 50 (DC50) of 7.9 nM in the NAMALWA Burkitt lymphoma cell line [1]. |
| In vivo | SJF620 hydrochloride demonstrates an excellent pharmacokinetic profile in mice at a dose of 1 mg/kg intravenously, featuring a half-life (t 1/2) of 1.64 hours. Notably, SJF620's pharmacokinetic parameters are significantly superior to those of MT802 [1]. |
| Molecular Weight | 797.3 |
| Formula | C41H45ClN8O7 |
| Cas No. | 2821938-05-8 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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