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SP-96

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Purity:99.52%

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COA HPLC HNMR

SP-96

Catalog No. T41256Cas No. 2682114-54-9

SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negative breast cancer studies.

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Pack Size	Price	Availability
1 mg	$67	In Stock
5 mg	$163	In Stock
10 mg	$263	In Stock
25 mg	$513	In Stock
50 mg	$747	In Stock
100 mg	$1,050	In Stock
1 mL x 10 mM (in DMSO)	$178	In Stock

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Product Introduction

Bioactivity

Description

In vitro

SP-96 (63.2 nM) inhibits Aurora B activity in H460 cells by the characteristics of increased DNA content, and it increases cell volume with enormous nucleus. SP-96 shows >2000 fold selectivity against FLT3 (IC50=1475.6 nM) and KIT (IC50=1307.6 nM). SP-96 (0-2 µM) inhibits Aurora A with IC50 value of 18.975 nM. SP-96 (0-1 µM; 24 hours) is not promiscuous, rather selective for a few cell lines, it inhibits MDA-MB-468, CCRF-CEM, COLO 205 and A498 cell growth with GI50 values of 107 nM,47.4 nM, 50.3 nM and 53.2 nM, respectively[1].

Chemical Properties

Molecular Weight	453.47
Formula	C25H20FN7O
Cas No.	2682114-54-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (209.50 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2052 mL	11.0261 mL	22.0522 mL	110.2609 mL
5 mM	0.4410 mL	2.2052 mL	4.4104 mL	22.0522 mL
10 mM	0.2205 mL	1.1026 mL	2.2052 mL	11.0261 mL
20 mM	0.1103 mL	0.5513 mL	1.1026 mL	5.5130 mL
50 mM	0.0441 mL	0.2205 mL	0.4410 mL	2.2052 mL
100 mM	0.0221 mL	0.1103 mL	0.2205 mL	1.1026 mL

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In Vivo Formulation Calculator (Clear solution)

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Tech Support

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