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SR-1114
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Catalog No. T81108Cas No. 2769141-82-2
SR-1114, a first-in-class PROTAC ENL degrader, induces rapid CRBN-dependent ENL degradation with DC50 values of 150 nM in MV4;11 cells, 311 nM in MOLM-13 cells, and 1.65 μM in OCI/AML-2 cells [1].
SR-1114
😃Good
Catalog No. T81108Cas No. 2769141-82-2
SR-1114, a first-in-class PROTAC ENL degrader, induces rapid CRBN-dependent ENL degradation with DC50 values of 150 nM in MV4;11 cells, 311 nM in MOLM-13 cells, and 1.65 μM in OCI/AML-2 cells [1].
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Product Introduction
Bioactivity
Chemical Properties
| Description | SR-1114, a first-in-class PROTAC ENL degrader, induces rapid CRBN-dependent ENL degradation with DC50 values of 150 nM in MV4;11 cells, 311 nM in MOLM-13 cells, and 1.65 μM in OCI/AML-2 cells [1]. |
| In vitro | Certainly, here is a revised version of the sentence: 'Ser nM TPP nM CUR (7)' is a chemical compound that exhibits specific activity, engaging in targeted interactions within a designated chemical or biological context. The notation encapsulates its unique structure and function. (Note: The sentence provided was incomplete and lacked context. I've crafted a general revision that addresses a typical description of chemical compound activity while retaining the original elements in parentheses and brackets. If there was additional information or specific jargon intended to be included, please provide the full sentence or context for more accurate assistance.) |
| In vivo | Ser nM TPP nM CUR (4 mg/kg; i.v. once) exhibits improved renal tissue distribution through KIM-1-receptor-mediated endocytosis within renal tubular epithelial cells, and it enhances the renal function in mice with acute kidney injury (AKI) [1]. |
| Molecular Weight | 830.86 |
| Formula | C39H42N8O11S |
| Cas No. | 2769141-82-2 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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