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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | Backorder | |
5 mg | $483 | Backorder | |
10 mg | $692 | Backorder | |
25 mg | $1,080 | Backorder |
Description | STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various diseases [1]. |
In vitro | STAT3 degrader-2 (Compound 92) at various concentrations (0.2 μM, 1 μM, 30 nM, 100 nM, 300 nM) for 3 hours significantly reduces the total STAT3 protein levels in acute leukemia Molm-16 cells [1]. |
In vivo | STAT3 degrader-2 (Compound 92) administered intravenously at a dosage of 50 mg/kg at 6, 24, and 48-hour intervals, reduced the levels of total STAT3 protein and phosphorylated STAT3 (Y705) in the Molm-16 acute leukemia tumor model and in SU-DHL-1 mouse tumors [1]. Additionally, STAT3 degrader-2 showed antitumor activity against Molm-16 xenograft tumors in mice when administered intravenously once weekly (qw) at dosages of 25 and 50 mg/kg [1]. |
Molecular Weight | 1136.15 |
Formula | C59H62N9O13P |
Cas No. | 2497583-03-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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