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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | Backorder |
Description | Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs. |
Targets&IC50 | p38β:90 nM, p38α:9 nM |
In vitro | Talmapimod hydrochloride inhibits LPS-induced TNF-a production in human whole blood. Talmapimod hydrochloride decreases constitutive p38alpha MAPK phosphorylation of both 5T2MM and 5T33MM cells. Talmapimod hydrochloride (100-200 nM; 1 hour) inhibits phosphorylation of p38 MAPK in MM cells [1][2][3]. |
In vivo | Talmapimod hydrochloride (10-90 mg/kg; P.o.; twice daily for 14 days) dose-dependently reduced both tumor growth and the weight of palpable tumors at termination [4]. |
Alias | SCIO-469 hydrochloride |
Molecular Weight | 549.47 |
Formula | C27H31Cl2FN4O3 |
Cas No. | 309915-12-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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