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Talmapimod hydrochloride

Catalog No. T12871LCas No. 309915-12-6
Alias SCIO-469 hydrochloride

Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs.

Talmapimod hydrochloride

Talmapimod hydrochloride

Catalog No. T12871LAlias SCIO-469 hydrochlorideCas No. 309915-12-6
Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs.
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Product Introduction

Bioactivity
Description
Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs.
Targets&IC50
p38β:90 nM, p38α:9 nM
In vitro
Talmapimod hydrochloride inhibits LPS-induced TNF-a production in human whole blood. Talmapimod hydrochloride decreases constitutive p38alpha MAPK phosphorylation of both 5T2MM and 5T33MM cells. Talmapimod hydrochloride (100-200 nM; 1 hour) inhibits phosphorylation of p38 MAPK in MM cells [1][2][3].
In vivo
Talmapimod hydrochloride (10-90 mg/kg; P.o.; twice daily for 14 days) dose-dependently reduced both tumor growth and the weight of palpable tumors at termination [4].
AliasSCIO-469 hydrochloride
Chemical Properties
Molecular Weight549.47
FormulaC27H31Cl2FN4O3
Cas No.309915-12-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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