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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,420 | 10-14 weeks | |
50 mg | $3,180 | 10-14 weeks | |
100 mg | $4,300 | 10-14 weeks |
Description | TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM). |
In vitro | IKKε and TBK1 are serine/threonine kinases and are highly homologous to other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognized by Toll-like receptors 3 and 4 and RNA helicases RIG-1 and MDA-5, and lead to the activation of the TRIF-TBK1/IKKε-IRF3 signaling cascade, resulting in type I interferon. response. |
Molecular Weight | 498.53 |
Formula | C28H26N4O5 |
Cas No. | 2058264-32-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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