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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $30 | In Stock | |
100 mg | $40 | In Stock | |
200 mg | $56 | In Stock | |
500 mg | $92 | In Stock | |
1 g | $133 | In Stock | |
1 mL x 10 mM (in DMSO) | $44 | In Stock |
Description | TDCPP (Fyrol FR 2) is classified under the chlorinated trialkyl organophosphate flame retardant (OPFR) group of compounds primarily utilized as additives in commercial products. |
In vitro | A dose-dependent decrease of cell viability after TDCPP exposure with LC50 at 202 μg/mL. A concentration-dependent apoptotic sign was observed in HCECs after exposing to ≥2 μg/mL TDCPP. Endoplasmic reticulum stress induction was evidenced by up-regulation of its biomarker genes (ATF-4, CHOP, BiP, and XBP1). Furthermore, alternation of Bcl-2/Bax expression, mitochondrial membrane potential loss, cellular ATP content decrease, and caspase-3 and -9 activity increase were observed after exposing to 2 or 20 μg/mL TDCPP. Implicated the involvement of endoplasmic reticulum stress in TDCPP-induced HCEC apoptosis, probably mediated by mitochondrial apoptotic pathway. TDCPP exposure induced toxicity to human cornea. |
Cell Research | Human corneal epithelial cells (HCECs) were cultured in DMEM supplemented with 10% FBS, 10 ng/mL EGF, and 1% penicillin-streptomycin solution in an incubator with 5% CO2 at 37℃.?After reaching confluence, HCECs were replanted into 6/24/ 96-well plates or petri dishes with different initial densities and cultured for 24 h to reach ~70% confluence.?Then, TDCPP dissolved in n-hexane was solvent-exchanged to DMSO and serially diluted by DMEM to achieve concentrations from 0.034 to 340 μg/mL.?For cell exposure, the culture medium was aspirated and treated with TDCPP solutions (DMSO <0.1%) for 24 h with 0.1% DMSO solution as vehicle control[1]. |
Alias | Fyrol FR 2, Tris(1,3-dichloroisopropyl)phosphate |
Molecular Weight | 430.9 |
Formula | C9H15Cl6O4P |
Cas No. | 13674-87-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (139.24 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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