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TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM)
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $40 | In Stock | |
2 mg | $57 | In Stock | |
5 mg | $95 | In Stock | |
10 mg | $163 | In Stock | |
25 mg | $319 | In Stock | |
50 mg | $578 | In Stock | |
100 mg | $833 | In Stock | |
500 mg | $1,690 | In Stock | |
1 mL x 10 mM (in DMSO) | $113 | In Stock |
Description | TH5487 is an potent inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)( IC50 of 342 nM) |
Targets&IC50 | OGG1:342 nM |
In vitro | TH5487 Inhibited proinflammatory gene expression dose-dependently. |
In vivo | TH5487 (prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours) decreases TNFα or LPS induced the robust recruitment of neutrophils to the airways, and reduces the pulmonary neutrophil count in a time-dependent manner. TH5487 InterruptedTNFα-induced ongoing inflammatory processes. |
Cell Research | Cell Line:Murine airway epithelial cell line (MLE 12); Diploid human small-airway epithelial cell (hSAECs). Concentration:5 μM. Incubation Time:1 hour |
Animal Research | Animal Model:Eightweek-old female and male BALB/c mice. Dosage:8 mg/kg, 15 mg/kg, 30 mg/kg. Administration:Prophylactic intraperitoneally injection; 8-30 mg/kg; 1-9 hours |
Molecular Weight | 541.18 |
Formula | C19H18BrIN4O2 |
Cas No. | 2304947-71-3 |
Smiles | Brc1cccc2n(C3CCN(CC3)C(=O)Nc3ccc(I)cc3)c(=O)[nH]c12 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (83.15 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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