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Topterone
Catalog No. T13187Cas No. 60607-35-4
Alias Win 17665
Topterone (Win 17,665) is a potent topical antiandrogen that inhibits the stimulation of lumbar organ development by testosterone and dihydrotestosterone in castrated immature male hamsters.
Topterone
Catalog No. T13187Alias Win 17665Cas No. 60607-35-4
Topterone (Win 17,665) is a potent topical antiandrogen that inhibits the stimulation of lumbar organ development by testosterone and dihydrotestosterone in castrated immature male hamsters.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $700 | 6-8 weeks | |
| 5 mg | $1,800 | 6-8 weeks |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Topterone (Win 17,665) is a potent topical antiandrogen that inhibits the stimulation of lumbar organ development by testosterone and dihydrotestosterone in castrated immature male hamsters. |
| In vivo | To determine its endocrine profile, Topterone is administered parenterally or topically to rats, rabbits, or hamsters. Systemic administration reveals that Topterone exhibits both antiandrogenic and progestational effects. However, topical application at a dose of 1 g/kg/day fails to induce a systemic antiandrogenic response, and only a minimal progestational response is observed at 32 mg/kg/day. No other endocrine activities are detected in these experiments[2]. Topterone demonstrates the inhibition of flank organ development in castrated immature male hamsters in response to both testosterone and dihydrotestosterone, whereas Progesterone inhibits stimulation by only testosterone. Furthermore, topical application of Topterone has been shown to cause regression in the development of the flank organ[1]. |
| Alias | Win 17665 |
| Molecular Weight | 330.5 |
| Formula | C22H34O2 |
| Cas No. | 60607-35-4 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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