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TT-012

🥰Excellent
Catalog No. T77743Cas No. 1164471-33-3

TT-012 has anti-tumor activity, selectively binds dynamic MITF and disrupts the dimer formation and DNA binding of the latter. TT-012 can inhibit the transcription of MITF in B16F10 melanoma cells. TT-012 inhibited the growth and metastasis of MITF melanoma cells in animal models. TT-012 is less cytotoxic to liver and immune cells.

TT-012

TT-012

🥰Excellent
Purity: 99.91%
Catalog No. T77743Cas No. 1164471-33-3
TT-012 has anti-tumor activity, selectively binds dynamic MITF and disrupts the dimer formation and DNA binding of the latter. TT-012 can inhibit the transcription of MITF in B16F10 melanoma cells. TT-012 inhibited the growth and metastasis of MITF melanoma cells in animal models. TT-012 is less cytotoxic to liver and immune cells.
Pack SizePriceAvailabilityQuantity
1 mg$38 In Stock
5 mg$89 In Stock
10 mg$147 In Stock
25 mg$297 In Stock
50 mg$488 In Stock
100 mg$788 In Stock
500 mg$1,590 In Stock
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Purity:99.91%
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Product Introduction

Bioactivity
Description
TT-012 has anti-tumor activity, selectively binds dynamic MITF and disrupts the dimer formation and DNA binding of the latter. TT-012 can inhibit the transcription of MITF in B16F10 melanoma cells. TT-012 inhibited the growth and metastasis of MITF melanoma cells in animal models. TT-012 is less cytotoxic to liver and immune cells.
Chemical Properties
Molecular Weight349.34
FormulaC19H15N3O4
Cas No.1164471-33-3
SmilesN(C(/C=C/C1=CC=CO1)=O)C=2N=C(NC(/C=C/C3=CC=CO3)=O)C=CC2
Relative Density.1.385 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (286.25 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8625 mL14.3127 mL28.6254 mL143.1270 mL
5 mM0.5725 mL2.8625 mL5.7251 mL28.6254 mL
10 mM0.2863 mL1.4313 mL2.8625 mL14.3127 mL
20 mM0.1431 mL0.7156 mL1.4313 mL7.1564 mL
50 mM0.0573 mL0.2863 mL0.5725 mL2.8625 mL
100 mM0.0286 mL0.1431 mL0.2863 mL1.4313 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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