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Tuna AI acetate

🥰Excellent
Catalog No. T24906L

Tuna AI acetate is an inhibitor of angiotensin-converting enzyme (ACE) in non-competitive manner derived from tuna muscle.

Tuna AI acetate

Tuna AI acetate

🥰Excellent
Purity: 98.49%
Catalog No. T24906L
Tuna AI acetate is an inhibitor of angiotensin-converting enzyme (ACE) in non-competitive manner derived from tuna muscle.
Pack SizePriceAvailabilityQuantity
1 mg$117In Stock
2 mg$165In Stock
5 mg$262In Stock
10 mg$388In Stock
25 mg$592In Stock
50 mg$828In Stock
100 mg$1,110In Stock
200 mg$1,480In Stock
1 mL x 10 mM (in DMSO)$460In Stock
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Purity:98.49%
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Product Introduction

Bioactivity
Description
Tuna AI acetate is an inhibitor of angiotensin-converting enzyme (ACE) in non-competitive manner derived from tuna muscle.
Targets&IC50
Ang I:5.7 μM(rabbit lung ACE), Hippuryl-L-histidyl-L-leucine:1.7 μM(rabbit lung ACE)
In vitro
Tuna AI acetate inhibited rabbit lung ACE non-competitively with Ki values of 1.7 and 5.7 microM with substrates, hippuryl-L-histidyl-L-leucine and angiotensin I, respectively. Tuna AI acetate (5.3 microM) also doubled the effect of bradykinin in the contraction of isolated guinea pig ileum[1].
Chemical Properties
Molecular Weight1013.1
FormulaC46H68N12O14
SmilesCC(O)=O.O=C(O)C[C@@H](C(O)=O)NC(CNC([C@H](CC1=CNC2=C1C=CC=C2)NC([C@H](CCCCN)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CNC=N3)NC([C@H]([C@H](O)C)NC([C@H]4NCCC4)=O)=O)=O)=O)=O)=O)=O
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 22.5 mg/mL (22.21 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.9871 mL4.9353 mL9.8707 mL49.3535 mL
5 mM0.1974 mL0.9871 mL1.9741 mL9.8707 mL
10 mM0.0987 mL0.4935 mL0.9871 mL4.9353 mL
20 mM0.0494 mL0.2468 mL0.4935 mL2.4677 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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