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Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type. It demonstrates notable antiproliferative effects on Ba/F3 cells expressing CD74-TRKA G667C and ETV6-TRKC G696C, with half-maximal inhibitory concentrations (IC50s) of 6 nM and 1.7 nM, respectively [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $1,370 | 8-10 weeks | |
50 mg | $2,780 | 8-10 weeks | |
100 mg | $3,700 | 8-10 weeks |
Description | Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type. It demonstrates notable antiproliferative effects on Ba/F3 cells expressing CD74-TRKA G667C and ETV6-TRKC G696C, with half-maximal inhibitory concentrations (IC50s) of 6 nM and 1.7 nM, respectively [1]. |
In vitro | Type II TRK inhibitor 1 (compound 7b) at concentrations ranging from 3.1 to 800 nM and a 2-hour incubation period inhibits the phosphorylation of TRKA, PLCγ1, and ERK [1]. |
Molecular Weight | 670.68 |
Formula | C35H33F3N8O3 |
Cas No. | 2937543-72-9 |
Storage | Shipping with blue ice. |
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