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Type II TRK inhibitor 1
Type II TRK inhibitor 1
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Type II TRK inhibitor 1
Catalog No. T72289Cas No. 2937543-72-9
Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type. It demonstrates notable antiproliferative effects on Ba/F3 cells expressing CD74-TRKA G667C and ETV6-TRKC G696C, with half-maximal inhibitory concentrations (IC50s) of 6 nM and 1.7 nM, respectively [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,370 | 8-10 weeks | |
| 50 mg | $2,780 | 8-10 weeks | |
| 100 mg | $3,700 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type. It demonstrates notable antiproliferative effects on Ba/F3 cells expressing CD74-TRKA G667C and ETV6-TRKC G696C, with half-maximal inhibitory concentrations (IC50s) of 6 nM and 1.7 nM, respectively [1]. |
| In vitro | Type II TRK inhibitor 1 (compound 7b) at concentrations ranging from 3.1 to 800 nM and a 2-hour incubation period inhibits the phosphorylation of TRKA, PLCγ1, and ERK [1]. |
| Molecular Weight | 670.68 |
| Formula | C35H33F3N8O3 |
| Cas No. | 2937543-72-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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