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VEGFR-2-IN-9

🥰Excellent
Catalog No. T10123Cas No. 408502-06-7
Alias KDR-in-4

VEGFR-2-IN-9 (KDR-in-4) is a potent KDR/VEGFR2 inhibitor with an IC50 of 7 nM, suitable for breast cancer research.

VEGFR-2-IN-9

VEGFR-2-IN-9

🥰Excellent
Purity: 97.19%
Catalog No. T10123Alias KDR-in-4Cas No. 408502-06-7
VEGFR-2-IN-9 (KDR-in-4) is a potent KDR/VEGFR2 inhibitor with an IC50 of 7 nM, suitable for breast cancer research.
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1 mg665 €In Stock
5 mg1.710 €In Stock
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Purity:97.19%
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Product Introduction

Bioactivity
Description
VEGFR-2-IN-9 (KDR-in-4) is a potent KDR/VEGFR2 inhibitor with an IC50 of 7 nM, suitable for breast cancer research.
Targets&IC50
KDR:7 nM
In vitro
One of the human tyrosine kinases with a high affinity for vascular endothelial growth factor (VEGF) is KDR (kinase insert domain-containing receptor), believed to be a primary mediator of tumor-induced angiogenesis[2].
In vivo
KDR-in-4, at doses of 100 mg/kg, results in a 98% reduction in lesion size in the rat choroidal neovascularization (CNV) model, demonstrating potential utility for the treatment of various ocular neovascular diseases through a convenient oral dosing regimen. In the laser CNV and rat oxygen-induced retinopathy (OIR) models, 30 mg/kg doses of KDR-in-4 exhibit reductions in lesion size of 70% and 80%, respectively[1].
AliasKDR-in-4
Chemical Properties
Molecular Weight391.46
FormulaC23H25N3O3
Cas No.408502-06-7
SmilesO=C1NC=2C=CC=CC2C=C1C3=CC4=CC(OCCN(C)CCOC)=CC=C4N3
Relative Density.1.235 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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