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Virodhamine

Catalog No. T64371 CAS 287937-12-6

Synonyms: O-arachidonoyl ethanolamine

Virodhamine, an endocannabinoid, is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine can be used for the research of neurological disorders such as Alzheimer's diseases.

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Virodhamine, CAS 287937-12-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Virodhamine, an endocannabinoid, is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine can be used for the research of neurological disorders such as Alzheimer's diseases.
In vitro	virodhamine (50nM, 72h) treatment augmented features associated with megakaryocytic development: cells increased adherence and membrane expansion. virodhamine (10, 20, 40 µM, 72h) treatment increases the expression of CD61[1].
In vivo	Virodhamine (1, 5, 10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in Male ICR mice[2].

Synonyms	O-arachidonoyl ethanolamine
Molecular Weight	347.53
Formula	C22H37NO2
CAS No.	287937-12-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 90mg/mL (259mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sharma DS, et al. Virodhamine, an endocannabinoid, induces megakaryocyte differentiation by regulating MAPK activity and function of mitochondria. J Cell Physiol. 2021 Feb;236(2):1445-1453. 2. Hayase T. Working memory- and anxiety-related behavioral effects of repeated nicotine as a stressor: the role of cannabinoid receptors. BMC Neurosci. 2013 Feb 9;14:20.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Virodhamine 287937-12-6 GPCR/G Protein Cannabinoid Receptor O-arachidonoyl ethanolamine Inhibitor inhibitor inhibit

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