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VU6004909
🥰Excellent
Catalog No. T79784Cas No. 1860797-76-7
Alias VU 6004909
VU6004909 is a potent mGlu5 receptor orthosteric modulator (EC50:25.7nM) that reverses MK801-induced cortical activity enhancement and cognitive dysfunction, and can be used in the study of neurological disorders.
VU6004909
🥰Excellent
Purity: 98.44%
Catalog No. T79784Alias VU 6004909Cas No. 1860797-76-7
VU6004909 is a potent mGlu5 receptor orthosteric modulator (EC50:25.7nM) that reverses MK801-induced cortical activity enhancement and cognitive dysfunction, and can be used in the study of neurological disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $36 | In Stock | |
| 5 mg | $79 | In Stock | |
| 10 mg | $126 | In Stock | |
| 25 mg | $249 | In Stock | |
| 50 mg | $398 | In Stock | |
| 100 mg | $639 | In Stock |
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Purity:98.44%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | VU6004909 is a potent mGlu5 receptor orthosteric modulator (EC50:25.7nM) that reverses MK801-induced cortical activity enhancement and cognitive dysfunction, and can be used in the study of neurological disorders. |
| Targets&IC50 | mGlu1 (human):25.7 nM (EC50), mGlu1 (rat):31 nM (EC50) |
| In vitro | VU6004909 is a blood-brain barrier-penetrating orthosteric modulator of mGlu1 with half-maximal effective concentrations (EC50) of 25.7 nM [2] and 31 nM [1] for human- and rat-derived mGlu1, respectively. |
| Alias | VU 6004909 |
| Molecular Weight | 378.35 |
| Formula | C21H15FN2O4 |
| Cas No. | 1860797-76-7 |
| Smiles | O=C(NC1=CC=C(C=C1F)N2C(=O)C3=CC=C(C=C3C2=O)C)C=4OC=CC4C |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (10.57 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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