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ZXH-3-26
🥰Excellent
Catalog No. T17297Cas No. 2243076-67-5
ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.
ZXH-3-26
🥰Excellent
Purity: 98.90%
Catalog No. T17297Cas No. 2243076-67-5
ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $230 | In Stock |
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Purity:98.90%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer. |
| Targets&IC50 | BRD4:5 nM （DC50） |
| In vitro | BRD4 degradation was determined using 100 nM ZXH-3-26. Obvious degradation of BRD4 was observed after 30 min, and complete depletion was observed after 4 h. [2] |
| Molecular Weight | 785.27 |
| Formula | C38H37ClN8O7S |
| Cas No. | 2243076-67-5 |
| Smiles | CC=1C2=C(N3C([C@H](CC(OC)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)SC1C(NCCCCCNC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)=O |
| Relative Density. | 1.55 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 160 mg/mL (203.75 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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