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ZXH-4-130 TFA
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Catalog No. T77920Cas No. 2711006-67-4
ZXH-4-130 TFA is a hetero-PROTAC (CRBN-VHL compound) that efficaciously and selectively mediates the degradation of CRBN, achieving approximately 80% degradation at a concentration of 10 nM in MM1.S cells [1].
ZXH-4-130 TFA
😃Good
Catalog No. T77920Cas No. 2711006-67-4
ZXH-4-130 TFA is a hetero-PROTAC (CRBN-VHL compound) that efficaciously and selectively mediates the degradation of CRBN, achieving approximately 80% degradation at a concentration of 10 nM in MM1.S cells [1].
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Product Introduction
Bioactivity
Chemical Properties
| Description | ZXH-4-130 TFA is a hetero-PROTAC (CRBN-VHL compound) that efficaciously and selectively mediates the degradation of CRBN, achieving approximately 80% degradation at a concentration of 10 nM in MM1.S cells [1]. |
| In vitro | ZXH-4-130 TFA at a concentration of 100 nM and pre-treatment for 2 hours significantly inhibited the cytotoxic effects of pomalidomide (1 μM) when cells were subsequently treated for 96 hours, displaying a statistically significant protective effect [1]. Additionally, a pre-treatment with ZXH-4-130 TFA at 50 nM was able to rescue the degradation of GSPT1 in MM1.S cells induced by CC-885 [1]. Furthermore, ZXH-4-130 TFA (100 nM; pre-treated for 2 hours, followed by treatment with THAL-SNS-032 for 6 hours) nearly completely induced the degradation of CRBN, whereas THAL-SNS-032 only partially inhibited CDK9 activity [1]. |
| Molecular Weight | 985.08 |
| Formula | C48H59F3N6O11S |
| Cas No. | 2711006-67-4 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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