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PACAP (1-27), human, ovine, rat acetate

🥰Excellent
Catalog No. TP1070L
Alias PACAP 1-27 acetate, PACAP (1-27), human, ovine, rat acetate(127317-03-7 free base)

PACAP (1-27), human, ovine, rat acetate (PACAP 1-27 acetate) is a novel neuropeptides originally isolated from bovine hypothalamus, also found in humans and rats.

PACAP (1-27), human, ovine, rat acetate
Other Forms of PACAP (1-27), human, ovine, rat acetate:

PACAP (1-27), human, ovine, rat acetate

🥰Excellent
Purity: 98%
Catalog No. TP1070LAlias PACAP 1-27 acetate, PACAP (1-27), human, ovine, rat acetate(127317-03-7 free base)
PACAP (1-27), human, ovine, rat acetate (PACAP 1-27 acetate) is a novel neuropeptides originally isolated from bovine hypothalamus, also found in humans and rats.
Pack SizePriceAvailabilityQuantity
1 mg$153In Stock
5 mg$450In Stock
10 mg$663In Stock
25 mg$987In Stock
50 mg$1,390In Stock
100 mg$1,880In Stock
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Purity:98%
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Product Introduction

Bioactivity
Description
PACAP (1-27), human, ovine, rat acetate (PACAP 1-27 acetate) is a novel neuropeptides originally isolated from bovine hypothalamus, also found in humans and rats.
In vitro
Radioligand receptor binding assays with I-monoiodinated PACAP (1-27), human, ovine, rat confirms the presence of PAC -receptors on AR4-2J cells, since PACAP (1-27), human, ovine, rat and PACAP(1–38) equipotently displaces radioligand binding with a Kd of 1-2 nM, whereas vasoactive intestinal peptide (VIP) is 1000-fold less potent. PACAP (1-27), human, ovine, rat exhibits a distinct and much higher susceptibility to VIP-amino acid substitutions. PACAP (1-27), human, ovine, rat has potency and binding affinity to stimulate IP3 and cAMP formation in AR4-2J cells[2].
In vivo
The inhibitory effect of pituitary adenylate cyclase activating polypeptide (PACAP (1-27), human, ovine, rat) on the increase in total pulmonary resistance (RL) causes either by allergen or histamine in anaesthetized, ventilated guinea-pigs is studied. PACAP (1-27), human, ovine, rat given via i.v. infusion (0.045-4.5 nmol/kg/min) dose-dependently reduces the increase in RL caused by inhaled ovalbumin and histamine. At the highest dose, PACAP (1-27), human, ovine, rat prevented the increase in RL caused by ovalbumin and histamine completely. Infusion of PACAP (1-27), human, ovine, rat and the β2-adrenoceptor agonist, salbutamol (0.045-4.5 nmol/kg/min) inhibit the increase in RL similarly, but salbutamol increases the heart rate more than PACAP (1-27), human, ovine, rat[3].
AliasPACAP 1-27 acetate, PACAP (1-27), human, ovine, rat acetate(127317-03-7 free base)
Chemical Properties
Molecular Weight3207.71
FormulaC144H228N40O41S
SmilesO=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@H](C(N)=O)CC(C)C)=O)=O)=O)=O)=O)CC1=CC=C(O)C=C1)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC([C@H](CC(O)=O)NC([C@@]([C@H](O)C)([H])NC([C@@H](NC([C@@]([C@@H](C)CC)([H])NC(CNC([C@H](CC(O)=O)NC([C@H](CO)NC([C@@H](N)CC2=CNC=N2)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)CC5=CC=C(O)C=C5.CC(O)=O
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 5 mM
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.3117 mL1.5587 mL3.1175 mL15.5874 mL
5 mM0.0623 mL0.3117 mL0.6235 mL3.1175 mL

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Keywords

PACAP 1-27 AcetatePACAP , human, ovine, rat AcetatePACAP (127), human, ovine, rat acetatePACAP (1 27), human, ovine, rat acetate
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