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(R)-(-)-Rolipram

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Purity:99.6%

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COA HPLC HNMR

(R)-(-)-Rolipram

Catalog No. T13448Cas No. 85416-75-7

(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.

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Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$62	In Stock
10 mg	$98	In Stock
25 mg	$189	In Stock
50 mg	$352	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock

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Product Introduction

Bioactivity

Description	(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.
In vitro	The reduction of (R)-(-)-rolipram on cAMP hydrolysis and the increasement of adenylyl cyclase activator forskolin on cAMP synthesis in a dose-dependent manner inhibits caspase-1 cleavage and IL-1β secretion[1].
Alias	(R)-Rolipram, (-)-Rolipram

Chemical Properties

Molecular Weight	275.34
Formula	C16H21NO3
Cas No.	85416-75-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (345.03 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6319 mL	18.1594 mL	36.3187 mL	181.5937 mL
5 mM	0.7264 mL	3.6319 mL	7.2637 mL	36.3187 mL
10 mM	0.3632 mL	1.8159 mL	3.6319 mL	18.1594 mL
20 mM	0.1816 mL	0.9080 mL	1.8159 mL	9.0797 mL
50 mM	0.0726 mL	0.3632 mL	0.7264 mL	3.6319 mL
100 mM	0.0363 mL	0.1816 mL	0.3632 mL	1.8159 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc