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12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LOE. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 μg | $328 | 35 days | |
50 μg | $615 | 35 days | |
100 μg | $1,160 | 35 days | |
250 μg | $2,570 | 35 days |
Description | 12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LOE. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex. |
Molecular Weight | 336.47 |
Formula | C20H32O4 |
Cas No. | 71774-10-2 |
Smiles | [C@@H](/C=C/C=C\C/C=C\CCCC(O)=O)(C/C=C\CCCCC)OO |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
Solubility Information | PBS (pH 7.2): < 1 mg/ml (slightly soluble or insoluble), Sonication is recommended. 0.1 M Na2CO3: 1 mg/mL (2.97 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
0.1 M Na2CO3
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