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2-Hydroxy-3-methoxy chalcone
🥰Excellent
Catalog No. TN7226Cas No. 7146-86-3
2-Hydroxy-3-methoxy chalcone has anticancer activity and inhibits colon cancer.
2-Hydroxy-3-methoxy chalcone
🥰Excellent
Purity: 99.55%
Catalog No. TN7226Cas No. 7146-86-3
2-Hydroxy-3-methoxy chalcone has anticancer activity and inhibits colon cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $117 | In Stock | |
| 5 mg | $258 | In Stock | |
| 10 mg | $382 | In Stock | |
| 25 mg | $592 | In Stock |
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Purity:99.55%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 2-Hydroxy-3-methoxy chalcone has anticancer activity and inhibits colon cancer. |
| Targets&IC50 | mTOR:21 µM |
| In vitro | 2'-hydroxy-3'-methoxychalcone (TJ3) (10 µM and 25 µM ) significantly reduced the release of ICAM-1 by SW480 cancer cells. It did not have a significant effect on VCAM-1 released by SW480 and SW620 cancer cell lines. However, it demonstrated a significant dose-dependent reduction in the concentration of MIF on SW480 cells. Additionally, TJ3 at a concentration of 25 µM significantly decreased IL-8 secretion by both SW480 and SW620 cancer cells. These results indicate that the tested TJ3 exhibits a modulating effect on colon cancer cells.[1] |
| Molecular Weight | 254.28 |
| Formula | C16H14O3 |
| Cas No. | 7146-86-3 |
| Smiles | C(=CC(=O)C1=C(O)C=CC=C1)C2=CC(OC)=CC=C2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (176.97 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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