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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $747 | 6-8 weeks | |
100 mg | $1,390 | 6-8 weeks |
Description | 360A iodide is a selective G-quadruplex stabilizer that inhibits telomerase activity (IC50: 300 nM in TRAP-G4 assay). |
Targets&IC50 | Telomerase:300 nM |
In vitro | 360A reduces the viability of glioma cell lines, such as CB193, T98G, U118-MG, SAOS-2, and Primary astrocytes, with IC50s of 3.9 μM, 4.8 μM, 8.4 μM, >15 μM and 17.4 μM, respectively [1]. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions [2]. |
Cell Research | In brief, cells are seeded at various densities, depending on cell type (0.25-4 × 10^3 cells/well in 100?μL complete medium), in 96-well culture plates and treated with various concentrations (0.1-20?μM) of 360A or the corresponding concentrations of DMSO (control wells) for 3 or 7 days at 37°C in an atmosphere containing 5% CO2. For 7-day assays, the medium is changed on day 3. Experiments are performed in triplicate [1]. |
Alias | 360 A iodide |
Molecular Weight | 703.31 |
Formula | C27H23I2N5O2 |
Cas No. | 737763-37-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
Solubility Information | DMSO: 2 mg/mL (2.84 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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