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5,6-trans-Vitamin D3

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Purity:97.90%

ee:100%

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COA CSFC HNMR HPLC LCMS

5,6-trans-Vitamin D3

Catalog No. T35501Cas No. 22350-41-0

5,6-trans-Vitamin D3（5,6-trans-Cholecalciferol） is an isoform of Vitamin D3, which is converted from Vitamin D3 on the skin surface after light exposure.

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Pack Size	Price	Availability
1 mg	$83	In Stock
5 mg	$198	In Stock
10 mg	$339	In Stock
25 mg	$566	In Stock
50 mg	$791	In Stock
100 mg	$1,090	In Stock
500 mg	$2,190	In Stock

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Product Introduction

Bioactivity

Description	5,6-trans-Vitamin D3（5,6-trans-Cholecalciferol） is an isoform of Vitamin D3, which is converted from Vitamin D3 on the skin surface after light exposure.
In vitro	The dissociation constants of vitamin D receptor (VDR) for 25-hydroxytachysterol3, 25-hydroxy-5,6-trans-vitamin D3, and 5,6-trans-vitamin D3 were 22, 58, and 560 nM, respectively. The dissociation constants for 7-dehydrocholesterol, tachysterol, and lumisterol were greater than 20 microM. In conclusion, vitamin D3, its photoisomers and the photoisomers of previtamin D3 have antiproliferative activity in cultured human keratinocytes.[1].
Alias	5,6-trans-Colecalciferol, 5,6-trans-Cholecalciferol, Cholecalciferol EP Impurity A

Chemical Properties

Molecular Weight	384.64
Formula	C27H44O
Cas No.	22350-41-0

Storage & Solubility Information

Storage

keep away from direct sunlight,store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 30 mg/mL

DMF: 10 mg/mL (26.00 mM)

Ethyl Acetate: 20 mg/mL (52.00 mM)

DMSO: 1 mg/mL (2.60 mM)

Solution Preparation Table

Ethyl Acetate/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5998 mL	12.9992 mL	25.9983 mL	129.9917 mL

Ethyl Acetate

	1mg	5mg	10mg	50mg
5 mM	0.5200 mL	2.5998 mL	5.1997 mL	25.9983 mL
10 mM	0.2600 mL	1.2999 mL	2.5998 mL	12.9992 mL
20 mM	0.1300 mL	0.6500 mL	1.2999 mL	6.4996 mL
50 mM	0.0520 mL	0.2600 mL	0.5200 mL	2.5998 mL
100 mM	0.0260 mL	0.1300 mL	0.2600 mL	1.2999 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc